The primary role of type 2 immunity is to defend our bodies against parasitic infections. However, in some individuals, this immune response becomes hyper-reactive, and can lead to allergic diseases affecting multiple organs, with symptoms varying from mild to severe. 

Conditions associated with type 2 inflammation include atopic dermatitis, prurigo nodularis, CRSwNP, and asthma. These conditions can significantly impact an individual’s quality of life, often causing chronic discomfort and various health challenges.1,2

Atopic Dermatitis (AD)

For those with AD, the relentless itch, redness, and dry skin become unwelcome daily companions. AD is characterized by chronic inflammation, fueled by an overactive immune system. Many with AD also experience other allergic conditions, such as food allergies, chronic sinusitis, or asthma.3

Prurigo Nodularis (PN)

PN is a skin condition characterized by intensely itchy skin and painful bumps that can appear anywhere on the body after chronic scratching.4 The persistent itch can disrupt sleep, daily activities and the quality of life for people suering from this condition.5
 

Chronic Rhinosinusitus with Nasal Polyps (CRSwNP)

CRSwNP is a long-term inflammation of the nasal passages that results in burdensome, grape-like growths. These growths can disrupt breathing and dull your sense of smell, thereby impacting your quality of life. Beyond a mere congestion, CRSwNP is often charaterized by a long-term disease burden and poor quality of life (QoL).6

Asthma

Asthma transforms the simple act of breathing into a challenging task. In this chronic respiratory condition, narrowed airways result in symptoms like wheezing, coughing, and shortness of breath. It represents an overzealous immune system reacting to typically harmless substances in our environment such as pollen, dust mites, and pet dander.7

References:
1. Gandhi NA, et al. Nat Rev Drug Discov 2016;15:35-50.
2. Gandhi NA, et al. Expert Rev Clin Immunol 2017;13:425-437.
3. National Eczema Association. Atopic dermatitis in children. Available at: https://nationaleczema.org/eczema/children/atopic-dermatitis/. Accessed on September 2023.
4. Kwatra, SG. JAMA Dermatology 2022;158:336.
5. Kwatra SG. N Engl J Med 2020;382:757-758.
6. Hopkins C, et al. N Engl J Med 2019; 381:55-63.
7. World Health Organization. Asthma. Accessed on: 27 June, 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/asthma.

The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.