What is prurigo nodularis (PN)?

Have you ever had an itch so intense you can’t stop scratching? When you have prurigo nodularis (PN), you know this unbearable sensation all too well. PN is a chronic (long-lasting) inflammatory skin condition that is characterized by very intense itch, and bumps on the skin called nodules. The persistent itch can disrupt your sleep, daily activities and quality of life.1-4

PN, also known as nodular prurigo or Hyde’s disease, starts inside your body. Your skin, nervous system and immune system may not function in the way they would in individuals without PN.1,3 A type of inflammation called ‘type 2 inflammation’ may play a role in its signs and symptoms.5

Who is affected by PN?

PN can affect anyone, but it is more common among women and adults aged over 50 years.6,7 The condition can manifest on its own or be associated with other underlying diseases and dermatologic conditions, such as atopic dermatitis.1-4,6 A study conducted at a dermatological center in Singapore found that 82% of patients with extensive PN had other underlying dermatological conditions. Notably, endogenous eczema was the most commonly identified disease, comprising 54% of cases.6 Endogenous forms of eczema include atopic dermatitis, seborrhoeic dermatitis, pompholyx, varicose eczema, xerotic eczema and discoid eczema.8

1. National Organization for Rare Diseases. Prurigo Nodularis. Available at: https://rarediseases.org/rare-diseases/prurigo-nodularis/. Accessed August 2023.
2. Aggarwal P, et al. Clin Exp Dermatol 2021;46(7):1277–1284.
3. Ryan S. Dermatol Nurs 2017;16(4):18–21.
4. Yale Medicine. Prurigo Nodularis. Available at: https://www.yalemedicine.org/conditions/prurigo-nodularis-overview. Accessed August 2023.
5. Williams KA et al. J Am Acad Dermatol 2020; 83(6): 1567–1575.
6. Tan WS, Tey HL. Dermatology 2014;228(3):276–80.
7. Wikström K, et al. Acta Derm Venereol 2021 Jul 30;101(7):adv00508.
8. Vega-Lopez F, Ritchie S. Dermatological Problems. In: Farrar J, Hotez PJ, Junghanss T, eds. Manson’s Tropical Infectious Diseases. Saunders Ltd; 2014: 995–1026.

The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.